
Understanding Spinal Muscular Atrophy vs Duchenne Muscular Dystrophy: Key Differences and Awareness
Genetic disorders like spinal muscular atrophy and Duchenne muscular dystrophy are often misunderstood due to their complex nature. Both conditions impact muscle function but arise from different genetic mutations and affect individuals in distinct ways. Understanding these differences is essential for accurate diagnosis, tailored care, and effective support systems. Spinal muscular atrophy is caused by a deficiency in the survival motor neuron (SMN) protein due to mutations in the SMN1 gene. This deficiency leads to the degeneration of motor neurons, resulting in muscle weakness and atrophy. The severity of SMA varies, with Type 1 being the most severe and often appearing in infancy, while Type 4 manifests in adulthood. Duchenne muscular dystrophy, however, is caused by mutations in the DMD gene, which encodes dystrophin, a protein critical for muscle integrity. Without dystrophin, muscles progressively weaken, leading to loss of mobility and other complications, typically beginning in early childhood. Symptoms and Progression The symptoms of SMA and DMD differ significantly. SMA primarily affects motor neurons, leading to muscle weakness, difficulty breathing, and challenges with movement. In severe cases, infants may struggle with swallowing and breathing. DMD, however, presents with progressive muscle weakness, starting in the legs and pelvis, and eventually affecting the heart and respiratory muscles.